The British director, who directed 1986 Tom Cruise led original to box office success, told HitFix that the movie will examine how air combat has changed in the past two decades.
"It's a whole different world now," he said. "These computer geeks - these kids play war games in a trailer in Fallon, Nevada and if we ever went to war or were in the Middle East or the Far East or wherever it is, these guys can actually fly drones. They are unmanned aircraft. They operate them and then they party all night."
Scott noted that he met one of the new breed of fighter pilots on a recent flight back from Las Vegas.
He explained: "The guy sitting next to me was all hungover. He must have been in his late 20s and he was one of these kids. He said, 'I partied all night.' And I said, 'What do you do?' 'I work [with unmanned aircraft in] the Air Force.' They operate these drones like it's war games, but it's for real."
Scott refused to comment on a potential return for Cruise's Maverick character, but said that many pilots who flew in the '80s still flew test aircraft and were the first people to operate the drones.